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From the Editor-in-Chief
Why Do Targeted Therapies Stop Working?Researchers seek to understand why cancers stop responding to targeted treatments even after initially dramatic responses.
by William G. Nelson, MD, PhD, DSc
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Forward Look
Tumor Testing DelaysMedical oncologist Umang Swami notes the importance of educating patients about the value of tumor testing.
by Lindsey Leake
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Forward Look
Boosting Chemotherapy’s EffectivenessTargeted treatment that blocks glucocorticoid receptors appears to disrupt signaling that helps ovarian cancer cells withstand chemotherapy.
by Cameron Walker
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Forward Look
Chemotherapy at HomeA pilot program shows some people with cancer may safely receive chemotherapy at home.
by Laura Gesualdi Gilmore
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Forward Look
Hormone Therapy After Prostate Cancer SurgeryStudy shows that adding hormone therapy to postoperative radiation did not improve overall survival in men with low PSA levels.
by Ashley P. Taylor
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Forward Look
Is Nicotine Vaping Safer Than Smoking Cigarettes?For those using e-cigarettes to stop smoking, nicotine vaping comes with its own health risks.
by Brianna Abbott
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The Expanding Role of ADCsAs some antibody-drug conjugates move into first-line and early-stage treatment, researchers seek new targets, payloads and combinations to reach more types of cancer.
by Kendall K. Morgan
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Choosing Your Next MoveCAR T-cell therapies and bispecific antibodies offer options for people with relapsed or refractory multiple myeloma.
by Jo Cavallo
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Q&A
Broadening the Reach of Lung Cancer ScreeningLung cancer survivor Shira Kupperman Boehler makes the case for earlier, more readily available screening.
by Darcy Lewis
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Sound Advice
What can people with cancer expect during their first chemotherapy appointment?An oncology nurse offers advice for people about to begin chemotherapy, addressing how long visits will take and what to bring with them.
The ‘Your Friends & Neighbors’ actress explains how her diagnosis challenged many of her assumptions about breast cancer.
by Darlene Dobkowski
Why I Participated in a Clinical TrialWhen doctors told Yvonne McLean Florence she was eligible to participate in a research trial testing an experimental drug, she joined. She wants more people to have the same opportunity.
by Yvonne McLean Florence
Targeted Therapy Improves Pancreatic Cancer SurvivalA recently approved drug that targets RAS proteins meaningfully improves outcomes for people with this difficult-to-treat cancer.
by Sandra Gordon
Bring On the WavesA surfer’s love for the ocean guides her through breast cancer treatment and beyond.
by Cameron Walker
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AACR OMB Statement and Call to ActionThe AACR is deeply concerned that proposed OMB regulations would disrupt federal research grant giving, severely weakening a program that has supported American medical innovation for decades.
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AACR Cancer Disparities Progress ReportThe AACR Cancer Disparities Progress Report 2026 highlights recent progress in reducing cancer disparities and emphasizes the continued need for transformative research.
Cancer Research at a Crossroads
