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Clinical Trial Considerations

Learn what questions to ask before participating in a study. By Hester Hill Schnipper

A lot of the knowledge we have about current treatments comes from clinical trials. You may be wondering if an experimental drug might be better than your current treatment plan.

​Hester Hil​l Schnipper | Photo courtesy of Beth Israel Deaconess Medical Center​
Remember that studies strive to provide answers that are not yet known. Occasionally, a treatment in a clinical trial turns out to be a home run. More often, these newer approaches are only a bit better than standard treatments, and they can be less effective. In fact, a recent study found that only one in 20 oncology drugs tested in phase I trials eventually receive U.S. Food and Drug Administration approval.  

Still, some cancer patients decide to take part in a drug trial, hoping for a personal benefit but also seeking to contribute to science. It’s a common misconception that you must have advanced disease to participate in these types of studies. In fact, numerous clinical trials are available to patients at all stages of their disease. (A searchable registry of clinical trials is available at

Here are some questions to ask before participating in a clinical trial.

1) Am I good candidate for a clinical trial? What are the potential benefits of my participation? What are the potential downsides for me? 

Drug Trials 101​
Familiarize yourself with clinical trial phases.
2) How much will my insurance cover? Many clinical trials are funded by government agencies or pharmaceutical companies, which often pay for the cost of experimental medications, extra blood tests and scans given for research purposes. Most insurance plans are required to cover routine patient care costs during a clinical trial. Plans are not required to cover out-of-network doctors if they are not part of your insurance coverage.

3) How many extra trips to the hospital will be needed? Will there be extra blood draws or scans? 

4) Are there alternatives, including standard treatments, that I should 
also be considering?

5) What effects will participation in this trial have on my daily life?

You can change your mind and withdraw from a trial at any time. But before agreeing to take part, do your homework and be realistic.  You aren’t signing up for a miracle; you are signing up to help doctors gather information. It is a bonus if the treatment also helps you.

HESTER HILL SCHNIPPER, a licensed independent clinical social worker, is a breast cancer survivor and the manager of oncology social work at Beth Israel Deaconess Medical Center in Boston. She also writes a blog, Living With Breast Cancer, for the hospital’s website.​​​​​​​​​


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